Changes in inflammatory parameters and their impact on clinical symptoms in patients suffering from schizophrenia

Introduction One of the factors influencing symptoms schizophrenia, which may indicate changes in cognitive functioning patients, is fluctuating level inflammatory cytokines. Objectives The aim review was to analyze available literature on importance selected [interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis α (TNF-α)] schizophrenia and assessment impact cytokine levels occurrence symptoms. Methods For this purpose, scientific publications from following databases: PubMed, Scopus, Google Scholar were used prove that parameters changed people suffering schizophrenia. Moreover, fluctuations concentrations influenced negative including disorders, as well psychotic Results An increase concentration IL-1β cerebrospinal fluid patients with first episode has been described, involvement process involving CNS. increased IL-6 associated it also noted stressful conditions. qualified an indicator exacerbation normalizes after antipsychotic treatment. In blood paranoid elevated IL-8 detected compared healthy individuals, indicates development relationship between women second trimester pregnancy risk developing spectrum disorder children proven. Untreated acute showed TNF-α serum (compared subjects). relapse or psychosis demonstrated. conclusion, appearance mood, behavior, dysfunction, children, reduced IL-10 intensification symptoms, deficits. Conclusions analysis fluctuate cytokines, affects clinical Disclosure Interest None Declared